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The research in my lab applies experimental molecular genomic, mathematical and computational approaches to investigate the regulation of gene expression during development. The major focus is on analyzing the epigenetic and regulatory networks that control transcription in the embryo in model insect species, including Drosophila and social insects.
Degrees
- Ph.D. in Molecular & Developmental Biology, King's College, University of Cambridge, 1999
- B.S. in Molecular Genetics, King's College, University of London, 1996
Affiliated Department(s)
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Scholarly and Creative Works
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Rapid and efficient purification of Drosophila homeodomain transcription factors for biophysical characterization
Protein expression and purification
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2019
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Vol. 158
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Analyzing the stability of gene expression using a simple reaction-diffusion model in an early Drosophila embryo
Mathematical biosciences
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2019
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Vol. 316
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Biophysical and structural analysis of Antennapedia and Ultrabithorax homeodomain transcription factor-DNA binding affinities
Protein Science●
2019
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Vol. 28
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Biophysical and structural analysis of Drosophila transcription factors
Protein Science●
2019
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Vol. 28
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Biophysical and structural analysis of Drosophila transcription factors
Next-in-BIO 2018
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Worcester MA
November
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2018
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Spatial distribution of predicted transcription factor binding sites in Drosophila ChIP peaks
Mechanisms of development
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2016
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Vol. 141
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Nucleotide Interdependency in Transcription Factor Binding Sites in the Drosophila Genome
Gene regulation and systems biology
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2016
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Vol. 10
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Parent-of-origin effects on genome-wide DNA methylation in the Cape honey bee (Apis mellifera capensis) may be confounded by allele-specific methylation
BMC genomics
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2016
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Vol. 17
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MARZ: an algorithm to combinatorially analyze gapped n-mer models of transcription factor binding
BMC bioinformatics
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2015
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Vol. 16
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Global sensitivity analysis of a dynamic model for gene expression in Drosophila embryos
PeerJ
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2015
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Vol. 3
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Awards & Grants
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Investigating the molecular mechanisms of transcriptional regulation at Drosophila homeotic genes
National Institutes of Health
May. 1, 2020 - Apr. 30, 2023
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Decoding cis-regulatory grammar at Hox genes
National Institutes of Health
Apr. 1, 2016 - Mar. 31, 2020
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Grant Incentive Award
Clark University
2020
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