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The research in my lab applies experimental molecular genomic, mathematical and computational approaches to investigate the regulation of gene expression during development. The major focus is on analyzing the epigenetic and regulatory networks that control transcription in the embryo in model insect species, including Drosophila and social insects.
Degrees
- Ph.D. in Molecular & Developmental Biology, King's College, University of Cambridge, 1999
- B.S. in Molecular Genetics, King's College, University of London, 1996
Affiliated Department(s)
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Scholarly and Creative Works
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Rapid and efficient purification of Drosophila homeodomain transcription factors for biophysical characterization
Protein expression and purification
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2019
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Vol. 158
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Analyzing the stability of gene expression using a simple reaction-diffusion model in an early Drosophila embryo
Mathematical biosciences
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2019
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Vol. 316
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Biophysical and structural analysis of Antennapedia and Ultrabithorax homeodomain transcription factor-DNA binding affinities
Protein Science●
2019
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Vol. 28
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Biophysical and structural analysis of Drosophila transcription factors
Protein Science●
2019
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Vol. 28
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Biophysical and structural analysis of Drosophila transcription factors
Next-in-BIO 2018
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Worcester MA
November
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2018
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Spatial distribution of predicted transcription factor binding sites in Drosophila ChIP peaks
Mechanisms of development
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2016
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Vol. 141
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Nucleotide Interdependency in Transcription Factor Binding Sites in the Drosophila Genome
Gene regulation and systems biology
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2016
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Vol. 10
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Parent-of-origin effects on genome-wide DNA methylation in the Cape honey bee (Apis mellifera capensis) may be confounded by allele-specific methylation
BMC genomics
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2016
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Vol. 17
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MARZ: an algorithm to combinatorially analyze gapped n-mer models of transcription factor binding
BMC bioinformatics
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2015
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Vol. 16
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Global sensitivity analysis of a dynamic model for gene expression in Drosophila embryos
PeerJ
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2015
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Vol. 3
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Whole-genome DNA methylation profile of the jewel wasp (Nasonia vitripennis)
G3 (Bethesda, Md.)
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2014
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Vol. 4
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Issue #3
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Deciphering the combinatorial architecture of a Drosophila homeotic gene enhancer
Mechanisms of development
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2014
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Vol. 131
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The dynamic DNA methylation cycle from egg to sperm in the honey bee Apis mellifera
Development (Cambridge, England)
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2014
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Vol. 141
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Issue #13
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A parent-of-origin effect on honeybee worker ovary size
Proceedings. Biological sciences
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2014
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Vol. 281
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Issue #1775
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Flanking sequence context-dependent transcription factor binding in early Drosophila development
BMC bioinformatics
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2013
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Vol. 14
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Kin conflict in insect societies: a new epigenetic perspective
Trends in ecology & evolution
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2012
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Vol. 27
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Issue #7
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Transcriptional repression by the proximal exonic region at the human TERT gene
Gene
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2011
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Vol. 486
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Issue #1-2
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Transcription factor binding site redundancy in embryonic enhancers of the Drosophila bithorax complex
G3 (Bethesda, Md.)
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2011
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Vol. 1
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Issue #7
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Molecular dissection of cis-regulatory modules at the Drosophila bithorax complex reveals critical transcription factor signature motifs
Developmental biology
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2011
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Vol. 359
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Issue #2
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Disruption of the abdominal-B promoter tethering element results in a loss of long-range enhancer-directed Hox gene expression in Drosophila
PloS one
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2011
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Vol. 6
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Issue #1
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Dissecting the regulatory switches of development: lessons from enhancer evolution in Drosophila
Development (Cambridge, England)
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2010
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Vol. 137
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Issue #1
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Characterization of an ultra-conserved putative cis-regulatory module at the mammalian telomerase reverse transcriptase gene
DNA and cell biology
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2010
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Vol. 29
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Issue #9
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Functional evolution of cis-regulatory modules at a homeotic gene in Drosophila
PLoS genetics
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2009
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Vol. 5
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Issue #11
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Whole genome bisulfite sequencing reveals a sparse, but robust pattern of DNA methylation in the Dictyostelium discoideum genome
BIORXIV
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Core promoter element sequence interdependencies are conserved from fly to human
Plos Computational Biology
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Incorporating parameter sensitivity improves the performance of an evolutionary algorithm
Bmc Bioinformatics
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Awards & Grants
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Investigating the molecular mechanisms of transcriptional regulation at Drosophila homeotic genes
National Institutes of Health
May. 1, 2020 - Apr. 30, 2023
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Decoding cis-regulatory grammar at Hox genes
National Institutes of Health
Apr. 1, 2016 - Mar. 31, 2020
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Grant Incentive Award
Clark University
2020
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