The research in my lab applies experimental molecular genomic, mathematical and computational approaches to investigate the regulation of gene expression during development. The major focus is on analyzing the epigenetic and regulatory networks that control transcription in the embryo in model insect species, including Drosophila and social insects.
Robert Drewell
Professor, Biology
- About
- Scholarly and creative works
- Awards and grant
Degrees
- Ph.D. in Molecular & Developmental Biology, King’s College, University of Cambridge, 1999
- B.S. in Molecular Genetics, King’s College, University of London, 1996
Affiliated Department
Scholarly and creative works
-
Biophysical and structural analysis of Drosophila transcription factors
Protein Science2019Vol. 28 -
Biophysical and structural analysis of Antennapedia and Ultrabithorax homeodomain transcription factor-DNA binding affinities
Protein Science2019Vol. 28 -
Analyzing the stability of gene expression using a simple reaction-diffusion model in an early Drosophila embryo
Published in Mathematical biosciences2019Vol. 316 -
Rapid and efficient purification of Drosophila homeodomain transcription factors for biophysical characterization
Published in Protein expression and purification2019Vol. 158 -
Biophysical and structural analysis of Drosophila transcription factors
Next-in-BIO 2018Worcester MANovember2018 -
Spatial distribution of predicted transcription factor binding sites in Drosophila ChIP peaks
Published in Mechanisms of development2016Vol. 141 -
Parent-of-origin effects on genome-wide DNA methylation in the Cape honey bee (Apis mellifera capensis) may be confounded by allele-specific methylation
Published in BMC genomics2016Vol. 17 -
Nucleotide Interdependency in Transcription Factor Binding Sites in the Drosophila Genome
Published in Gene regulation and systems biology2016Vol. 10 -
Global sensitivity analysis of a dynamic model for gene expression in Drosophila embryos
Published in PeerJ2015Vol. 3 -
MARZ: an algorithm to combinatorially analyze gapped n-mer models of transcription factor binding
Published in BMC bioinformatics2015Vol. 16 -
A parent-of-origin effect on honeybee worker ovary size
Published in Proceedings. Biological sciences2014Vol. 281Issue #1775 -
The dynamic DNA methylation cycle from egg to sperm in the honey bee Apis mellifera
Published in Development (Cambridge, England)2014Vol. 141Issue #13 -
Deciphering the combinatorial architecture of a Drosophila homeotic gene enhancer
Published in Mechanisms of development2014Vol. 131 -
Whole-genome DNA methylation profile of the jewel wasp (Nasonia vitripennis)
Published in G3 (Bethesda, Md.)2014Vol. 4Issue #3 -
Flanking sequence context-dependent transcription factor binding in early Drosophila development
Published in BMC bioinformatics2013Vol. 14 -
Kin conflict in insect societies: a new epigenetic perspective
Published in Trends in ecology & evolution2012Vol. 27Issue #7 -
Molecular dissection of cis-regulatory modules at the Drosophila bithorax complex reveals critical transcription factor signature motifs
Published in Developmental biology2011Vol. 359Issue #2 -
Transcription factor binding site redundancy in embryonic enhancers of the Drosophila bithorax complex
Published in G3 (Bethesda, Md.)2011Vol. 1Issue #7 -
Transcriptional repression by the proximal exonic region at the human TERT gene
Published in Gene2011Vol. 486Issue #1-2 -
Disruption of the abdominal-B promoter tethering element results in a loss of long-range enhancer-directed Hox gene expression in Drosophila
Published in PloS one2011Vol. 6Issue #1 -
Characterization of an ultra-conserved putative cis-regulatory module at the mammalian telomerase reverse transcriptase gene
Published in DNA and cell biology2010Vol. 29Issue #9 -
Dissecting the regulatory switches of development: lessons from enhancer evolution in Drosophila
Published in Development (Cambridge, England)2010Vol. 137Issue #1 -
Functional evolution of cis-regulatory modules at a homeotic gene in Drosophila
Published in PLoS genetics2009Vol. 5Issue #11 -
Incorporating parameter sensitivity improves the performance of an evolutionary algorithm
Published in Bmc Bioinformatics -
Core promoter element sequence interdependencies are conserved from fly to human
Published in Plos Computational Biology -
Whole genome bisulfite sequencing reveals a sparse, but robust pattern of DNA methylation in the Dictyostelium discoideum genome
Published in BIORXIV
Awards and grants
-
Investigating the molecular mechanisms of transcriptional regulation at Drosophila homeotic genes
National Institutes of Health
May. 1, 2020 – Apr. 30, 2023 -
Decoding cis-regulatory grammar at Hox genes
National Institutes of Health
Apr. 1, 2016 – Mar. 31, 2020