Noel Lazo

Professor, Chemistry

Noel Lazo is a Professor in the Carlson School of Chemistry and Biochemistry. His laboratory is currently focusing on the proteolytic degradation and aggregation of proteins associated with late onset disorders including Alzheimer’s disease and related dementias and type 2 diabetes. A combination of spectroscopic (e.g., NMR spectroscopy), spectrometric (e.g., mass spectrometry), and biochemical (e.g., limited proteolysis) methods is used to decipher mechanisms for protein oligomerization and proteolytic degradation. Since joining Clark in 2006, Dr. Lazo has mentored over 50 graduate and undergraduate students, some of whom have co-authored publications – a good indicator of their motivation and dedication to contribute to research associated with disease.  

Courses Taught:
CHEM 101 (Introductory Chemistry I, Lecture)
CHEM 102 (Introductory Chemistry II, Lecture)
CHEM 289 (Research Methods: Circular Dichroism Spectroscopy)
BCMB 264 (Biophysical Chemistry, Lecture + Laboratory)
BCMB 266 (Biomolecular NMR Spectroscopy)
BCMB 271 (Biochemistry I, Lecture)
BCMB 297 (Amyloid Proteins)

Degrees

  • Ph.D. in Chemistry, Solid-state NMR, Texas A&M University, 1991

Affiliated Departments

Chemistry, Biology

Scholarly and creative works

  • Article in Refereed Journal

    Differential Effects of Aβ Peptides on the Plasmin-Dependent Degradation of ApoE3 and ApoE4

    Published in ACS Chemical Neuroscience
    2025
    Vol. 16
    Issue #6
    Merc M Kemeh, Anthony J Furnelli, Noel Lazo
  • Article in Refereed Journal

    Highly Toxic Aβ Begets More Aβ

    Published in Neural Regeneration Research
    2024
    Vol. 19
    Issue #9
    Merc M. Kemeh, Noel D. Lazo
  • Other Scholarly or Creative Work

    How Aβ peptides modulate insulin degradation in Alzheimer’s and diabetes

    Merc M. Kemeh, Noel D. Lazo
  • Article in Refereed Journal

    Modulation of the Activity of the Insulin-degrading Enzyme by Aβ Peptides

    Published in ACS Chemical Neuroscience
    2023
    Vol. 14
    Merc M. Kemeh, Noel D. Lazo
  • Article in Refereed Journal

    Exchange Broadening Underlies the Enhancement of IDE-Dependent Degradation of Insulin by Anionic Membranes

    Published in ACS Omega
    2022
    2022
    Vol. 7
    Issue #28
    Qiuchen Zheng, Bethany Lee, Micheal T. Kebede, Valerie A. Ivancic, Merc M. Kemeh, Henrique Lemos Brito, Donald E. Spratt, Noel D. Lazo
  • Article in Refereed Journal

    Differential Effects of Polyphenols on Insulin Proteolysis by the Insulin-Degrading Enzyme

    Published in Antioxidants (Basel)
    2021
    2021
    Vol. 10
    Issue #9
    Qiuchen Zheng, Micheal T. Kebede, Bethany Lee, Claire A. Krasinski, Saadman Islam, Liliana A. Wurfl, Merc M. Kemeh, Valerie A. Ivancic, Charles E. Jakobsche, Donald E. Spratt, Noel D. Lazo
  • Article in Refereed Journal

    Helix Dipole and Membrane Electrostatics Delineate Conformational Transitions in the Self-Assembly of Amyloidogenic Peptides

    Published in Langmuir
    2020
    2020
    Vol. 36
    Issue #29
    Qiuchen Zheng, Senegal N. Carty, Noel D. Lazo
  • Article in Refereed Journal

    Inhibition of the Self-Assembly of Aβ and of Tau by Polyphenols: Mechanistic Studies

    Published in Molecules
    2019
    2019
    Vol. 24
    Issue #12
    Qiuchen Zheng, Micheal T. Kebede, Merc M. Kemeh, Saadman Islam, Bethany Lee, Stuart D. Bleck, Liliana A. Wurfl, Noel D. Lazo
  • Article in Refereed Journal

    Resveratrol Sustains Insulin-Degrading Enzyme Activity toward Aβ42

    Published in ACS Omega
    2018
    2018
    Vol. 3
    Issue #10
    Claire A. Krasinski, Valerie A. Ivancic, Qiuchen Zheng, Donald E. Spratt, Noel D. Lazo
  • Article in Refereed Journal

    Enzyme kinetics from circular dichroism of insulin reveals mechanistic insights into the regulation of insulin-degrading enzyme

    Published in Biosci Rep
    2018
    2018
    Vol. 38
    Issue #6
    Valerie A. Ivancic, Claire A. Krasinski, Qiuchen Zheng, Rebecca J. Meservier, Donald E. Spratt, Noel D. Lazo
  • Article in Refereed Journal

    The Longest Amyloid-β Precursor Protein Intracellular Domain Produced with Aβ42 Forms β-Sheet-Containing Monomers That Self-Assemble and Are Proteolyzed by Insulin-Degrading Enzyme

    Published in ACS Chem Neurosci
    2018
    2018
    Vol. 9
    Issue #12
    Claire A. Krasinski, Qiuchen Zheng, Valerie A. Ivancic, Donald E. Spratt, Noel D. Lazo
  • Article in Refereed Journal

    Mechanistic Studies of the Inhibition of Insulin Fibril Formation by Rosmarinic Acid

    Published in J Phys Chem B
    2018
    2018
    Vol. 122
    Issue #8
    Qiuchen Zheng, Noel D. Lazo
  • Article in Refereed Journal

    A versatile platform for adding functional properties to amyloid fibrils

    Published in Org Biomol Chem
    2017
    2017
    Vol. 15
    Issue #38
    Devon Fontaine, Valerie A. Ivancic, Michael B. Reardon, Noel D. Lazo, Charles E. Jakobsche
  • Article in Refereed Journal

    Binding Modes of Thioflavin T on the Surface of Amyloid Fibrils Studied by NMR

    Published in Chemphyschem
    2016
    2016
    Vol. 17
    Issue #16
    Valerie A. Ivancic, Oshini Ekanayake, Noel D. Lazo
  • Article in Refereed Journal

    K114 (trans, trans)-bromo-2,5-bis(4-hydroxystyryl)benzene is an efficient detector of cationic amyloid fibrils

    Published in Protein Sci
    2015
    2015
    Vol. 24
    Issue #3
    Veli Selmani, Kevin J. Robbins, Valerie A. Ivancic, Noel D. Lazo
  • Article in Refereed Journal

    Conformational analysis of thioflavin T bound to the surface of amyloid fibrils

    Published in Langmuir
    2012
    2012
    Vol. 28
    Issue #48
    Kevin J. Robbins, Gai Liu, Veli Selmani, Noel D. Lazo
  • Article in Refereed Journal

    Kinetic profile of amyloid formation in the presence of an aromatic inhibitor by nuclear magnetic resonance

    Published in ACS Med Chem Lett
    2012
    2012
    Vol. 3
    Issue #10
    Gai Liu, Jennifer C. Gaines, Kevin J. Robbins, Noel D. Lazo
  • Article in Refereed Journal

    Curcumin modulates the self-assembly of the islet amyloid polypeptide by disassembling α-helix

    Published in Biochem Biophys Res Commun
    2012
    2012
    Vol. 422
    Issue #4
    Samuel Sparks, Gai Liu, Kevin J. Robbins, Noel D. Lazo
  • Article in Refereed Journal

    Helix-dipole effects in peptide self-assembly to amyloid

    Published in Biochemistry
    2012
    2012
    Vol. 51
    Issue #20
    Gai Liu, Kevin J. Robbins, Samuel Sparks, Veli Selmani, Kalin M. Bilides, Erin E. Gomes, Noel D. Lazo
  • Article in Refereed Journal

    Mechanistic studies of peptide self-assembly: transient α-helices to stable β-sheets

    Published in J Am Chem Soc
    2010
    2010
    Vol. 132
    Issue #51
    Gai Liu, Anabathula Prabhakar, Darryl Aucoin, Miranda Simon, Samuel Sparks, Kevin J. Robbins, Andrew Sheen, Sarah A. Petty, Noel D. Lazo

Awards and grants

  • Determinants of the Proteolytic Degradation of Soluble Amyloid-beta

    National Institute on Aging/NIH

    clock icon Mar. 1, 2018 – Nov. 30, 2021